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![]() ![]() ![]() Neither Eck nor Melanchthon was pleased with the “long-winded and highly ambiguous article.” Their insistence on its inadequacy led the group to set the book aside in favor of open discussion. On the next day, April 28, attention turned to the controversial matter of justification. The first four articles, dealing with the creation of humans and their state before the fall free will the cause of sin and original sin went uncontested and unchanged by both groups. To the surprise of many in attendance, theological discussion revealed a considerable amount of agreement. The theological meeting came to be called the Colloquy of Regensburg. Cardinal Gasparo Contarini was papal legate, advising Catholic debaters behind the scenes. For the Roman Catholic Church were Johann Eck, Johann Gropper, and Julius Pflug. Philip Melanchthon, Martin Bucer, and Johann Pistorius represented the Protestants (a young John Calvin was present on the sideline). On April 21, 1541, the Emperor announced their names. This was a gathering of the Protestant intelligentsia bright sparks from both sides were chosen to participate. All of this meant that Charles V’s dream of unification among Catholics and Protestants was no small feat. Moreover, doctrinal slogans such as sola fide (faith alone) had become familiar throughout Europe. In 1530 Melanchthon finished editing the Augsburg Confession John Calvin completed his first edition of his magnum opus, Institutes of the Christian Religion, in 1536. Meanwhile, by the 1540s Protestant churches had established their basic theological convictions. Given the integral relationship of churc h and state in the pre-modern era, religious solidarity between Roman Catholics and Protestants was an important step toward the goal of political coherency in Europe. The Emperor simultaneously engineered a theological conference at Regensburg to accompany diplomatic sessions. The Original Evangelicals and Catholics TogetherĬontarini’s opportunity to engage Protestants in ecumenical dialogue came in April 1541 when Charles V organized an imperial conclave to unify his empire against threats from the outside. But unlike Luther, it also inspired an ecumenical spirit. The 20th-century Catholic historian Hubert Jedin has described it as a “tower experience.” As with Luther, this awakening led Contarini to a doctrine of imputation. It was “on Holy Saturday of 1511” when he “experienced a moment of illumination” that was likened to Luther’s epiphany, where “he was fully convinced that salvation could not be won by any human act but was God’s free gift and, as in Luther’s case, this conviction was accompanied by a perception that the monastery could not, for himself, procure an eternal blessedness.” This discovery left Contarini awestruck. Like Luther, Contarini’s crisis revolved around the question of how one secures divine forgiveness.Ī ray of hope eventually pierced Contarini’s dark cloud of doubt. This news deeply troubled Contarini and led him to reexamine his faith. On one occasion, his friend Tomasso Giustiniani wrote Contarini distressed that the Camaldoese Order of Hermits, which Giustiniani had recently entered, failed to provide certainty of salvation. Contarini Among FriendsĬontarini enjoyed discussing theology with friends. While much can be said about his career as an imperial diplomat, his elevation to the role of cardinal (1535), and his advocacy of the new Jesuit order (1540), we shall focus on his interaction with Protestants around the gospel. Trained in philosophy at the University of Padua, Contarini (1483-1542) became a champion of evangelical renewal in Italy. What is the fundamental difference between Roman Catholic and evangelical Protestant faith? The story of Cardinal Gasparo Contarini at Regensburg illustrates the answer. Castaldo highlights some fundamental divisions among Protestants and Catholics by exploring the role of one Catholic cardinal at Regensburg. We are pleased to share a recent piece at The Gospel Coalition by Chris Castaldo, with the permission of Castaldo and Dr. ![]() ![]() While it is easy for us to look on these worldviews as quaint or pitifully ignorant, our modern understanding of earthquakes and their origins is very recent (when my own father studied geology as part of his civil engineering education, the framework of plate tectonics for understanding geological events had yet to be formulated and published). Throughout history, peoples living in seismically active regions have formulated explanations for earthquakes, attributing their occurrence to the actions to disgruntled deities, mythical creatures or, later on, the Aristotelian view that earthquakes are caused by winds trapped and heated within a cavernous Earth (which is echoed in Shakespeare’s Henry IV, Part 1). The study of earthquakes serves many noble purposes, starting with humankind’s need to understand the planet on which we live and the causes of these calamitous events that challenge the very idea of residing on terra firma. While such practices may provide an impartial starting point for decision making regarding risk mitigation measures, the most promising avenue to achieve broad societal acceptance of the risks associated with induced earthquakes is through effective regulation, which needs to be transparent, independent, and informed by risk considerations based on both sound seismological science and reliable earthquake engineering. A more rational evaluation of seismic hazard and risk due to induced earthquakes may be facilitated by adopting, with appropriate adaptations, the advances in risk quantification and risk mitigation developed for natural seismicity. The challenge of achieving impartial acceptance of seismic hazard and risk estimates becomes even more acute in the case of earthquakes attributed to human activities. Despite these advances in the practice of seismic hazard analysis, it is not uncommon for the acceptance of seismic hazard estimates to be hindered by invalid comparisons, resistance to new information that challenges prevailing views, and attachment to previous estimates of the hazard. ![]() The next major evolutionary step was the identification of epistemic uncertainties related to incomplete knowledge, and the formulation of frameworks for both their quantification and their incorporation into hazard assessments. ![]() Over the last several decades, the practice of seismic hazard analysis has evolved enormously, firstly with the introduction of a rational framework for handling the apparent randomness in earthquake processes, which also enabled risk assessments to consider both the severity and likelihood of earthquake effects. ![]() Directly or indirectly, this generally requires quantification of the risk, for which quantification of the seismic hazard is required as a basic input. The fundamental objective of earthquake engineering is to protect lives and livelihoods through the reduction of seismic risk. ![]() ![]() ![]() In a September 28, 2021, interview, Slava admitted that he and Russian Blog Karina Karambeybi have been dating since February 2021. ![]() She has also featured in his music video for You Burn Like Fire. In 2015, Slava began experimenting with beat-making. ![]() On August 8, 2016, he created his YouTube channel. Among his first uploads were the music videos Donat (2016) and King of Snapchat (2017). In April 2019, he co-founded thee satirical music group Malchugeng along with N. Together, they released two Album|albums My Gang, which was, recorded in 12 hours, and Back and Forth, which was also recorded in one day. On July 27, 2019, Slava released his first solo album Opening under the pseudonym Manny. The album did not have a great reception, gaining fewer than 10,000 listeners. In October 2019, Slava began to collaborate with popular Russian hip hop star Morgenshtern. On February 12, 2020, he released the song Tik Tok Challenge, which became popular on the Application software Tik Tok. This sparked the usage of the hashtag #yamoguwottakvot on the app. As of August 2020, over 700,000 videos on TikTok have been made using this hashtag. On August 3, 2020, in an interview with Forbes, Slava talked about how he earned his first million dollars after moving to Moscow, teaching beat-making courses. On October 22, 2020, he uploded a video to his YouTube channel entitled Artyom in which he reveals his birth name and that an unknown group had Extortion large amounts of money from him for hiding his real name online. In the same video, he shared a story from his early life where, for an unknown reason, he began disliking his father, and in-turn, he stopped liking his last name, patronymic and first name, deciding to go by Slava Marlow instead. ![]() ![]() ![]() Elan tends to be more lenient on approvals and tends to grant (significantly) higher starting credit limits than its sister division. Bank's Elan division, the Everyday Rewards+. If credit line is an overriding concern, perhaps OP could consider getting the Altitude Go's sister card issued by U.S. One can pay biweekly, weekly, or even every few days. There is no need to wait for a statement to cut before paying. That said, I don't think utilization should be an overriding concern, because one can simply pay as you go. The old rule of a $5,000 minimum credit line for Signatures is no longer enforced by Visa as a network rule (although some issuers, particularly credit unions, still have their own internal policies requiring a minimum $5,000 credit line for Visa Signatures). Bank is known to issue Visa Signatures with credit limits as low as $500. ![]() We may make an exception if it's truly unique and helpful. ![]() Self-promotional posts must be pre-approved by a mod. Spamming other users will get you banned. This includes any behavior that could be deemed fishing for referrals. Don't post them don't hint at offering them don't ask for them. This applies to any posts where we suspect anything potentially illegal or fraudulent, and may include buying/selling tradelines. 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Furthermore, allogeneic MSC could be eliminated by CD8 + cytotoxic T lymphocytes, whereas transplanted autologous or allogeneic MSC could be eliminated by natural killer (NK) cells. Allogeneic MSC that engraft within target organs can lose their immune privileged status due to the surface expression of major histocompatibility complex class II as well as CD86, and be eliminated from the body due to the generation of anti-donor MSC antibodies. Elimination by adaptive immune cells and the loss of their immune privileged status can both contribute to the short half-life of transplanted MSC. Systemically delivered allogeneic MSC tend to accumulate in the lungs within the first 24 h of transplant those that escape entrapment by the lungs sequester within the liver and spleen. The half-life of transplanted MSC may be inadequate for tissue regeneration by MSC differentiation. The underlying concerns of the potential for tumor formation or differentiation into undesirable cell types have hindered the adoption and use of MSC-based therapeutic approaches, even though these risks remain unsubstantiated. These include the potential for aberrant differentiation, tumor formation and low engraftment. Moreover, MSC are capable of releasing proteins and extracellular vesicles (EV) that have been shown to directly modulate liver injury in different models.ĭespite their beneficial properties, there are several limitations to the use of MSC as cellular therapies. Furthermore, through the release of anti-inflammatory cytokines and factors, MSC have immunomodulatory effects on both the innate and adaptive immune systems (, 8]). Their capacity for diapedesis across the endothelium is enabled by the cell surface expression of chemokine receptors, adhesion antigens that ensure cell binding to the endothelium wall, and the expression and subsequent release of matrix metalloproteases (MMP) and other proteolytic enzymes. Next, they have migratory and homing capabilities that enable their sequestration into regions of injury. First, MSC have the capacity for multi-lineage differentiation into a myriad of different cell types. MSC have several characteristics that contribute to their reparative and regenerative properties. The secretome from MSC that are resident in the liver or MSC that are recruited to the liver could have functional effects. MSC from sites other than the liver such as the bone marrow can also be recruited to the liver when there is injury present. Liver MSC are elongated and spindle-shaped, and express stem-cell markers such as vimentin and MSC markers such as CD90, but not markers of hematopoietic stem cells such as CD45, or markers of other liver progenitor cells such as CK19. MSC are cells with differentiation capability which were first isolated from bone marrow but can be derived from perivascular cells from a number of tissues, including the liver. Regenerative therapies involving the use of MSC are a promising therapeutic approach for reducing liver injury, modulating the immune response to injury, and enhancing repair and regeneration of hepatic epithelia. Therapies that can repair or regenerate the liver in the setting of persistent injury or inflammation are needed to avoid reliance on replacement therapies such as transplantation which are not a viable option for many patients. ![]() In the absence of any effective therapies to ameliorate or reverse fibrotic changes, the only therapy currently available to those with advanced chronic liver disease is hepatic replacement with a liver transplant. The accumulation of fibrotic tissue may not be fully reversible, and can be progressive. If the injury or inflammation persists and the responses are unchecked, hepatic fibrosis can develop. ![]() Exposure to such insults can elicit tissue inflammation as well as result in innate and adaptive immune responses that could also directly contribute to further injury. Acute liver injury can occur as a consequence of ischemic, toxic–metabolic, cytotoxic or other insults. 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The 2019 Kidney Disease Outcomes Quality Initiative (KDOQI) clinical practice guidelines emphasized an individualized approach to HD access options as part of a patient’s ESRD life plan, encouraging “the right access, in the right patient, at the right time, for the right reason” ( 2). The majority of the nearly 4 million people with end-stage renal disease (ESRD) receiving renal replacement therapy worldwide do so via hemodialysis (HD) ( 1). Keywords: Hemodialysis (HD) fistula graft stenosis angioplasty Part two of this review will discuss the evolving role of DCBs, which seek to improve angioplasty outcomes. 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The highest available level of evidence regarding stenosis pathophysiology, angioplasty techniques, and approaches to treating different types of lesions within fistulas and grafts were included as part of this narrative review. Methods: An electronic search was performed on PubMed and EMBASE to identify relevant articles from 1980 to 2022. In part one of this two-part review, we aim to provide a comprehensive overview of the mechanisms of arteriovenous (AV) access stenosis, the evidence behind their treatment with high-quality plain balloon angioplasty techniques, and treatment considerations for specific stenotic lesions. Recent research has sought to improve patency rates utilizing antiproliferative drug-coated balloons (DCBs), however, their role in treatment has not yet been fully determined. 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